ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Ig heavy chain Mem5

Intermolecular
Cysteine 107 of Immunoglobulin kappa constant and cysteine 135
Intramolecular
Cysteine 147 and cysteine 202
A redox-regulated disulphide may form between cysteine 107 of Immunoglobulin kappa constant and cysteine 135 of Ig heavy chain Mem5 (219 and 136 respectively in this structure).

Details

Redox score ?
90
PDB code
2mpa
Structure name
bactericidal antibody against neisseria meningitidis
Structure deposition date
1999-06-09
Thiol separation (Å)
2
Half-sphere exposure sum ?
nan
Minimum pKa ?
nan
% buried
nan
Peptide A name
Immunoglobulin kappa constant
Peptide B name
Ig heavy chain Mem5
Peptide A accession
P01837
Peptide B accession
P84751
Peptide A residue number
107
Peptide B residue number
135

Ligandability

Cysteine 107 of Immunoglobulin kappa constant

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 135 of Ig heavy chain Mem5

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Ig heavy chain Mem5 between cysteines 147 and 202 (148 and 203 respectively in this structure).

Details

Redox score ?
79
PDB code
2mpa
Structure name
bactericidal antibody against neisseria meningitidis
Structure deposition date
1999-06-09
Thiol separation (Å)
2
Half-sphere exposure sum ?
86
Minimum pKa ?
nan
% buried
nan
Peptide accession
P84751
Residue number A
147
Residue number B
202
Peptide name
Ig heavy chain Mem5

Ligandability

Cysteine 147 of Ig heavy chain Mem5

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 202 of Ig heavy chain Mem5

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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